Igama elijwayelekile: | I-Tirzepatide |
Inombolo yeCas: | 2023788-19-2 |
I-Molecular Formula: | I-C225H348N48O68 |
Isisindo samangqamuzana: | 4813.45 g/mol |
Ukulandelana: | H-Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{diacid-gamma-Glu -(AEEA)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
Ukubukeka: | Impushana emhlophe |
Isicelo: | I-Tirzepatide iyisidakamizwa esicwaningwayo ukuze sisetshenziswe ekwelapheni isifo sikashukela sohlobo 2. Kungokwesigaba sezidakamizwa ezibizwa nge-diglucose-dependent insulinotropic peptide (GIP) kanye ne-glucagon-like peptide-1 (GLP-1) receptor agonists. I-Tezepatide isebenza ngokuvuselela ama-GIP nama-GLP-1 receptors emzimbeni. Lawa ma-receptors adlala indima ebalulekile ekulawuleni amazinga kashukela egazini kanye ne-metabolism. Ngokuvula la ma-receptors, i-tezepatide inyusa ukukhiqizwa kwe-insulin futhi yehlisa ukukhiqizwa kwe-glucagon, i-hormone enyusa amazinga kashukela egazini. Iphinde ibambezele ukuphuma kwesisu futhi isize ukulawula amazinga kashukela egazini. Ukuhlolwa kwemitholampilo kubonise ukuthi i-tilsiparatide ingalawula ngempumelelo amazinga kashukela egazini ezigulini ezinesifo sikashukela sohlobo 2. Kutholakale futhi ukukhuthaza ukulahlekelwa isisindo, okuyinzuzo eyengeziwe kubantu abaningi abanesifo sikashukela sohlobo lwe-2 abanobunzima bokugcina isisindo esinempilo. Enye yezinzuzo ze-tezeparatide uhlobo lwayo lokudosa olukanye ngeviki, olungase lwandise ukunethezeka nokuhambisana nohlelo lokwelapha. Lokhu kungase kube usizo ikakhulukazi kubantu abanobunzima bokunamathela kushejuli yemithi yansuku zonke noma abakhetha uhlelo lokwelapha olulula. Kufanele kuqashelwe ukuthi i-tilsparatide isesigabeni sokuphenya futhi ayikagunyazwa ukuthi isetshenziswe yizikhungo ezilawulayo. Ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukuphepha nokusebenza kwayo kwesikhathi eside kanye nokuhlonza noma yimiphi imiphumela emibi engaba khona. Kafushane, i-tilsiparatide umuthi omusha ophenywayo ekwelapheni isifo sikashukela sohlobo 2. Isenzo sayo esimbaxambili ku-GIP kanye ne-GLP-1 receptors sinamandla okuthuthukisa ukulawulwa kwe-glycemic nokuncipha kwesisindo. Kodwa-ke, ucwaningo olwengeziwe luyadingeka ngaphambi kokuthi i-tilsiparatide inconywe njengendlela yokwelapha yabantu abanesifo sikashukela sohlobo 2. |
Iphakheji: | isikhwama se-aluminium foil noma i-aluminium TIN noma ngokwezidingo zekhasimende ngalinye |
1 | Umhlinzeki oqeqeshiwe wama-API we-peptide ovela e-China. |
2 | Imigqa yokukhiqiza engu-16 enamandla okukhiqiza amakhulu anenani elincintisanayo |
3 | I-DMF itholakala nemibhalo ethembeke kakhulu. |
A: Yebo, singapakisha njengemfuneko yakho.
A: I-LC sight kanye ne-TT esikhathini sokukhokha kusengaphambili esikhethwayo.
IMP: Yebo, sicela unikeze ukucaciswa kwekhwalithi yakho, sizohlola i-R&D yethu futhi sizame ukufanisa ukucaciswa kwekhwalithi yakho.