Esivivinyweni sakamuva sesigaba sesi-3, i-Tirzepatide ibonise imiphumela ekhuthazayo ekwelapheni isifo sikashukela sohlobo 2. Umuthi utholakale unciphisa kakhulu amazinga kashukela egazini futhi ukhuthaze ukulahlekelwa isisindo ezigulini ezinesifo.
I-Tirzepatide iwumjovo wakanye ngeviki osebenza ngokukhomba i-glucagon-like peptide-1 (GLP-1) kanye ne-glucose-dependent insulinotropic polypeptide (GIP) receptors. Lawa ma-receptors adlala indima ebalulekile ekulawuleni amazinga kashukela egazini futhi akhuthaze ukukhiqizwa kwe-insulin.
Icala, eliqhutshwa u-Eli Lilly and Company, labhalisa abantu abangaphezu kwe-1,800 abanesifo sikashukela sohlobo 2 ababengayithathi i-insulin noma umthamo ozinzile we-insulin. Abahlanganyeli babelwa ngokungahleliwe ukuthi bathole imijovo yamasonto onke ye-Tirzepatide noma i-placebo.
Ekupheleni kocwaningo lwamasonto angama-40, abacwaningi bathola ukuthi iziguli ezathola i-Tirzepatide zazinezinga likashukela egazini eliphansi kakhulu kunalezo ezithole i-placebo. Ngokwesilinganiso, ababambiqhaza abaphathwa nge-Tirzepatide bathole ukwehliswa kwamazinga e-hemoglobin A1c (HbA1c) ngamaphesenti angu-2.5, uma kuqhathaniswa nokwehliswa kwamaphesenti angu-1.1 eqenjini le-placebo.
Ngaphezu kwalokho, iziguli ezithola i-Tirzepatide nazo zabhekana nokuncipha okukhulu kwesisindo. Ngokwesilinganiso, balahlekelwe ngamaphesenti angu-11.3 wesisindo somzimba wabo, uma kuqhathaniswa namaphesenti angu-1.8 eqenjini le-placebo.
Imiphumela yocwaningo ibaluleke kakhulu uma kubhekwa ukwanda kwesifo sikashukela sohlobo 2 emhlabeni wonke. NgokweWorld Health Organisation, isibalo sabantu abadala abaphila nesifo sikashukela siphindeke kane kusukela ngo-1980, kanti abantu abadala abalinganiselwa ezigidini ezingama-422 bathintekile ngo-2014.
"Ukulawula isifo sikashukela sohlobo 2 kungaba inselele kubantu abaningi, futhi izindlela ezintsha zokwelapha zamukelekile ngaso sonke isikhathi," kusho uDkt Juan Frias, umcwaningi oholayo ocwaningweni. "Imiphumela yalolu cwaningo iphakamisa ukuthi i-Tirzepatide ingase inikeze inketho entsha ethembisayo ezigulini ezinesifo sikashukela sohlobo lwe-2 ezinenkinga yokulawula amazinga kashukela egazini."
Nakuba ucwaningo olwengeziwe ludingeka ukuze kuhlolwe ukuphepha kwesikhathi eside nokusebenza kwe-Tirzepatide, imiphumela ekhuthazayo yomuthi kulesi sivivinyo sesigaba sesi-3 iwuphawu oluhle kubantu abanesifo sikashukela sohlobo 2. Uma kuvunywe ama-ejensi alawulayo, i-Tirzepatide inganikeza inketho entsha yokwelapha esebenzayo yokulawula isifo kanye nokuthuthukisa izinga lempilo yeziguli.
Isikhathi sokuthumela: Jun-03-2023