Ucwaningo olusha luthola ukuthi i-semaglutide yezidakamizwa ingasiza abantu abanesifo sikashukela sohlobo lwe-2 ukuba balahlekelwe isisindo futhi bagcine isikhathi eside.
I-Semaglutide iyisidakamizwa sokujova kanye ngesonto esivunywe yi-FDA ukwelapha uhlobo lwe-2 yesifo sikashukela. Umuthi usebenza ngokugqugquzela ukukhululwa kwe-insulin ekuphenduleni ukudla, okusiza ukulawula amazinga kashukela egazini. Ngaphezu kwalokho, i-semaglutide iphinde icindezele isifiso sokudla ngokusebenza esikhungweni se-satiety sobuchopho.
Ucwaningo, oluholwa abacwaningi eNyuvesi yaseCopenhagen, luqashe abantu abangu-1,961 abanesifo sikashukela sohlobo lwe-2 kanye ne-body mass index (BMI) ye-30 noma ngaphezulu. Abahlanganyeli babelwa ngezikhathi ezithile ukuze bathole imijovo yamasonto onke ye-semaglutide noma i-placebo. Bonke abahlanganyeli nabo bathola ukwelulekwa ngendlela yokuphila futhi bakhuthazwa ukuba balandele ukudla okunekhalori ephansi futhi bakhulise umsebenzi womzimba.
Ngemuva kwamasonto e-68, abacwaningi bathola ukuthi iziguli eziphathwe nge-semaglutide zilahlekelwe isilinganiso samaphesenti angu-14.9 wesisindo somzimba wabo, uma kuqhathaniswa namaphesenti angu-2.4 eqenjini le-placebo. Ngaphezu kwalokho, ngaphezu kwamaphesenti angu-80 weziguli eziphathwa nge-semaglutide zalahlekelwa okungenani amaphesenti angu-5 wesisindo somzimba wazo, uma kuqhathaniswa namaphesenti angu-34 weziguli eziphathwa nge-placebo. Ukulahlekelwa kwesisindo okuzuzwe nge-semaglutide kwagcinwa kuze kube yiminyaka engu-2.
Ucwaningo luphinde lwathola ukuthi iziguli eziphathwe nge-semaglutide zithole ukuthuthukiswa okuphawulekayo ekulawuleni ushukela wegazi, umfutho wegazi kanye namazinga e-cholesterol, konke okuyizici eziyingozi zesifo senhliziyo.
Imiphumela yalolu cwaningo iphakamisa ukuthi i-semaglutide ingaba yindlela yokwelapha ephumelelayo kubantu abanesifo sikashukela sohlobo lwe-2 abanenkinga yokulahlekelwa isisindo. Isheduli yokudosa yomuthi kanye ngeviki ikwenza kube inketho elula ezigulini okungenzeka zibe nobunzima bokunamathela kuhlelo lomthamo wansuku zonke.
Izinzuzo zokulahlekelwa kwesisindo se-semaglutide zingase zibe nomthelela obanzi ekwelapheni ukukhuluphala, isici esiyingozi esikhulu sohlobo lwe-2 yesifo sikashukela, isifo senhliziyo nezinye izifo ezingapheli. Ukukhuluphala ngokweqile kuthinta abantu abadala abangaphezu kwengxenye eyodwa kwezintathu e-United States, futhi ukwelashwa okusebenzayo kuyadingeka ukuze kubhekwane nale nkinga yezempilo yomphakathi ekhulayo.
Sekukonke, imiphumela yocwaningo iphakamisa ukuthi i-semaglutide ingaba isengezo esibalulekile ezinketho zokwelapha ezitholakalayo ezigulini ezinesifo sikashukela sohlobo lwe-2 nokukhuluphala. Kodwa-ke, njenganoma yimuphi umuthi, kubalulekile ukuthi iziguli zixoxisane nomhlinzeki wazo wokunakekelwa kwezempilo ngezingozi ezingaba khona kanye nezinzuzo futhi zilandele ngokucophelela umthamo obekiwe kanye neziyalezo zokuqapha.
Isikhathi sokuthumela: Jun-03-2019